Investigate Lymphangiogenesis in Carcinoma of Rectum of Human and Cancer Metastasis / 医学研究杂志

ABSTRACT

Objective To investigate the effects of vascular endothelial growth factor-C(VEGF-C)and VEGF-R3(fms-like tyrosine kinase-4,Flt-4)on lymphangiogenesis in adenocarcinoma of rectum.Methods A series of 32 adenocarcinoma of rectum were detected for the expression of VEGF-C and VEGF-R3(fms-like tyrosine kinase-4,Flt-4)and Podoplanin by immunohistochemical SABC methods.Results The density of lymphatic vessel in the perimeter of the adenocarcinoma tissue of rectum was much higher than in the interior(P