EFFECTS OF SOYBEAN ISOFLAVONES ON CELL CYCLES,CELL APOPTOSIS AND PROLIFERATION ON THYMOCYTES IN IRRADIATED MICE / 营养学报

ABSTRACT

To study the effect of soybean isoflavones(SI) on thymocytes in irradiated mice. Method: Ninety male mice were randomly divided into control group, irradiated group, irradiated plus 0.5% dose SI group. After 2w feeding, the mice received 4.0 Gy 137Cs ?-radiation. The cell cycles,cell apoptosis and proliferation of thymocytes and thymus index were observed in irradiated mice after 12h, 24h, 1w and 2w. Results: After the mice were irradiated, the thymus became significantly atrophic, and the rate of cell apoptos and the cell cycles of G0-G1 phase in thymocytes were significantly increased (P