Protective effects and mechanism of Rutoside on lung injury during experimental acute pancreatitis / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-559935
ABSTRACT
Aim To investigate effects and the mechanism of rutoside (Ru) on lung injury during experimental acute pancreatitis (AP) . Methods The model of AP was induced by retrograde injection of Sodium Taurocholate(STC)into biliopancreatic duct in rat. Ru (15,30,60 mg?kg -1 ?h -1 ) was administered by intravenous infusion for 6 hours immediately after the induction of AP. Indexes of blood gas analysis, the wet/dry lung ratio and pathological changes of lung tissue were observed and we also measured levels of TNF-?, ICAM-1and NF-?B. Result Ru(60 mg?kg -1 )increased the arterial PO_2, which decreased in AP rats. Ru (30,60 mg?kg -1 ) could decrease the wet/dry lung ratio, and improve pathological changes of lung tissue. Ru(15,30,60 mg?kg -1 ) could decrease levels of TNF-?, ICAM-1, and NF-?B. Conclusion The study indicates that Ru administered by intravenous infusion exerts certain protective effects on lung injury in experimental AP rats by decreasing levels of TNF-?, ICAM-1 and NF-?B.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2003
Tipo de documento:
Artigo
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