EFFECTS OF EARLY DIETARY COMPOSITIONS ON THYROXINE AND CARNITINE PALMITYL TRANSFERASE-ⅠGENE EXPRESSION IN RATS / 营养学报

ABSTRACT

Objective:To study the effects of early dietary compositions on body weight, body fat content, free thyroid hormoneT4(FT4)and carnitine palmityl transferase-Ⅰ(CPT-Ⅰ) gene expression in rats. Method:Male Wistar rats weaned on 24 d were randomly divided into A, B,C,D groups and were fed carbohydrate (basic), high protein, high unsaturated fatty acid and high saturated fatty acid diet respectively. After 3w, all rats were assigned to basic diet for 2w, and then rats from A group were randomly divided into groups A1 and A2. A1 was fed on basic diet continuously. Groups A2 ,B,C,D were assigned to high-fat diet for 6w. Body weight, body fat, blood glucose and FT4 ,and CPT-ⅠmRNA were observed in eight rats of every group. Results:Body weight, body fat and FT4 level in C group were significantly lower than those in A2 on 11w(P