Study on the effect of myeloperioxidase in rat colitis by oral administration of HPMCP-coated chitosan capsule filled with dexamethasone liposome lyophilized powder / 中国药理学通报

ABSTRACT

Aim To observe the inhibition of myeloperioxidase(MPO) activity in rat colitis by oral administration of HPMCP-coated chitosan capsule filled with dexamethasone(DSP) liposome lyophilized powder.Method The rat colitis was induced with the coloclysis of 2,4,6-trinitrobenzene sulfonic acid(TNBS),and then methods were established for quantifying MPO in colon tissue and the ratio of rat colon weight/rat body weight(C/B),which were chosen as the index of colitis degree.These indexes were used to evaluate the inhibiting action of various DSP dosage forms on MPO in colon tissue after their oral administration.Results The observed MPO in colon tissue reached the max on the fifth day with the coloclysis of TNBS.All the experimented DSP preparations could effectively inhibit MPO activity,while DSP lyophilized liposome capsule had the most effectiveness.Conclusion DSP lyophilized liposome chitosan capsule may be more helpful in treating colitis than DSP powder chitosan capsule and its other dosage forms.Hence,it is worth studying further.