Serum expression of monocyte chemoattractant protein-1 and macrophage inhibitory protein-1? in patients with rheumatoid arthritis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-560390
ABSTRACT
Objective:
To investigate the possible role of chemokines monocyte chemoattractant protein-1(MCP-1) and macrophage inhibitory protein-1(MIP-1?) in pathogenesis of rheumatoid arthritis(RA).Methods:
Enzyme linked immunosorbent assay(ELISA) was used to determine the serum expression of MCP-1 and MIP-1? in 17 patients with early active RA,18 with advanced active RA,and 15 healthy controls(all aged 18-79 years).Clinical activity indices such as the strength of grip,joint pain index,and joint swelling index were assessed in all subjects;and the serological indices such as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),and rheumatoid factors were also determined.The relationships between serum levels of MCP-1, MIP-1? with the clinical activity indices and serological indices were analyzed.Results:
The serum levels of MCP-1 in patients with early and advanced RA were higher than that in the controls(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2000
Tipo de documento:
Artigo
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