The effect of atorvastatin on pulmonary ischemia-reperfusion injury in rats / 中国基层医药

ABSTRACT

Objective To explore the protective effect of atorvastatin(Lipitor) on the acute lung injury with ischemia-reperfusion and its possible mechanism.Methods Single lung in site ischemia-reperfusion animal model was used.Thirty Wistar rats were randomly divided into three equal groups and 10 rats were in each groupsham operate group(SO),pulmonary models of ischemia-reperfusion injury(IR) and atorvastation treated group(AT).The two latter groups were all ischemia for 60 minutes followed by reperfusion for 120 minutes.In the AT group,each rat was treated with atorvastation(10mg/kg) for the seventh day.Wet to dry weight rate(W/D),lung permeability index(LPI) were measured respectively.Lung tissue was observed by light microscope.Immunohistochemical technique was used to determine the immunoractivity of nityic oxide synthase(NOS).Results The levels of LPI and W/D were significantly decreased in AT group than in IR group by statistically significant differences(P