Study on the Expression of PTENmRNA,P73mRNA and Clinicopathological Significances in the Benign and Malignant Lesions of Mammary Gland / 医学研究杂志

ABSTRACT

Objective To study on the expressions of PTENmRNA and P73mRNA and detect their clinicopathological significances in the benign and malignant lesions of mammary gland. Methods In situ hybridization method was used on the routinely paraffin-embedded sections for 40 cases with breast cancer and 30 ones with breast benign lesions. Results The positive rates of PTENmRNA was significantly lower in the breast cancer than that in breast benign lesions(P2cm and with-metastasis of lymphnode in breast cancer, but those of P73mRNA were opposite. The closely negative correlation was found between the expression of PTENmRNA and P73mRNA in breast cancer. Conclusions The pression of PTENmRNA or P73mRNA might be an important biological marker for the reflecting the carcinogenesis, progress, biological behaviors and prognosis of breast cancer. The detections of PTENmRNA and P73mRNA in the breast begin lesions might be important clinical values for early-stage prevention and treatment of breast cancer.