Bladder-preserving strategy for bladder tumor / 第三军医大学学报

ABSTRACT

Objective To discuss the bladder-preserving strategy for bladder tumor.Methods Totally 249 cases of bladder tumor were studied retrospectively.The analysis of overall recurrence rate,survival rate and the first recurrence-free duration according to operative methods,drugs for therapeutic bladder perfusion,and clinical stages was carried out.Results The first recurrence-free duration was not influenced by operative methods and perfusion drugs significantly.Although the overall recurrence rate and short-term survival rate were not influenced by operative methods,but the highest 10-year survival rate(77.3%) occurred in the patients received transurethral resection of bladder tumor(TURB).The recurrence rate,3-year,5-year and 10-year survival rate of the patients applied to different perfusion drug were statistically different,with the lowest recurrence rate (28.2%) in patients applied Bacillus Calmette-Guerin(BCG) and the highest survival rate was in patients applied BCG(3-year 100%,10-year 81.7%).According to clinical stage,the survival rate was of no statistical difference among patients belonging to T_(is),T_a,T_1 stages,and of significant difference between T_(2-4) and the other three stages.The overall recurrence rate were not significantly different among T_(is),T_a and T_(2-4) stages.Conclusion TURB combined with BCG perfusion produces favorable prognosis for bladder tumor patients without muscle-involved,while bladder-preserving operation is not beneficial for patients with muscle-involved bladder tumor.