Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549 / 第三军医大学学报

ABSTRACT

Objective To explore the mechanism of the alkaloids from tripterygium hypoglaucum hutch(THHa) on the apoptosis of lung cancer.Methods Apoptosis and cell cycle of human lung adenocarcinoma cell line A549 were detected by morphological observation,DNA electrophoresis,and flow cytometry.(Results THHa) could induce apoptosis of human lung adenocarcinoma cell line and arrest the cells at S phase of cell cycle.Conclusion Apoptosis contributes to inhibitory effect of THHa on A549 cells.This may be helpful in designing an appropriate chemotherapeutic regimen in future.