The role of histamine in immune reactions / 中国药理学通报

ABSTRACT

Immunologic cells not only express histamine receptors, most of them but also have the abilities to produce histamine. Histamine possesses extensive biologic effects on the components of the immune system, including the antigen presenting cells, T lymphocytes and antibody isotypes, and accordingly affects the pathological processes of the inflammation, immunological diseases and tumor. On the other hand, the various cytokines produced during immune responses can regulate the synthesis and release of histamine, as well as the expressions of histamine receptors.