Comparison of analgesic effects between methylene blue and adriamycin magnetic gelatin microballoons / 解放军医学杂志

ABSTRACT

Objective To compare the analgesic effects between methylene blue and adriamycin magnetic gelatin microballoons on blocking the cornu dorsale medullae spinalis of rabbit,and to investigate its mechanism.Methods 40 rabbits were randomly divided into 7 groups including sham operation group,gelatin microballoon controlled group(5mg and 15mg),methylene blue microballoon group(5mg and 15mg)and adriamycin microballoon group(5mg and 15mg).Under the guide of magnet,microballoons were infused into subarachnoid space of rabbits.The pain threshold of electronic stimulation and motor function of rabbits' hind limbs were observed continuously.The somatosensory evoked potential was recorded.Results The pain threshold was raised obviously(P