Nomogram to predict the number of oocytes retrieved in controlled ovarian stimulation / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 112-118, 2016.
Article
em En
| WPRIM
| ID: wpr-56129
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: Ovarian reserve tests are commonly used to predict ovarian response in infertile patients undergoing ovarian stimulation. Although serum markers such as basal follicle-stimulating hormone (FSH) or random anti-Müllerian hormone (AMH) level and ultrasonographic markers (antral follicle count, AFC) are good predictors, no single test has proven to be the best predictor. In this study, we developed appropriate equations and novel nomograms to predict the number of oocytes that will be retrieved using patients' age, serum levels of basal FSH and AMH, and AFC. METHODS: We analyzed a database containing clinical and laboratory information of 141 stimulated in vitro fertilization (IVF) cycles performed at a university-based hospital between September 2009 and December 2013. We used generalized linear models for prediction of the number of oocytes. RESULTS: Age, basal serum FSH level, serum AMH level, and AFC were significantly related to the number of oocytes retrieved according to the univariate and multivariate analyses. The equations that predicted the number of oocytes retrieved (log scale) were as follows: model (1) 3.21-0.036×(age)+0.089×(AMH), model (2) 3.422-0.03×(age)-0.049×(FSH)+0.08×(AMH), model (3) 2.32-0.017×(age)+0.039×(AMH)+0. 03×(AFC), model (4) 2.584-0.015×(age)-0.035×(FSH)+0.038×(AMH)+0.026×(AFC). model 4 showed the best performance. On the basis of these variables, we developed nomograms to predict the number of oocytes that can be retrieved. CONCLUSION: Our nomograms helped predict the number of oocytes retrieved in stimulated IVF cycles.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oócitos
/
Indução da Ovulação
/
Biomarcadores
/
Fertilização in vitro
/
Modelos Lineares
/
Análise Multivariada
/
Nomogramas
/
Reserva Ovariana
/
Hormônio Foliculoestimulante
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Clinical and Experimental Reproductive Medicine
Ano de publicação:
2016
Tipo de documento:
Article