Regional Cerebral Perfusion Abnormalities in Autistic Disorder: Statistical Parametric Mapping Analysis
Journal of the Korean Academy of Child and Adolescent Psychiatry
;
: 122-128, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-56171
ABSTRACT
OBJECTIVES:
Autism is a well-known psychiatric disorder that is presumed to have a neural basis. To investigate the underlying neurofunctional abnormalities of autism, the authors performed single photon emission computed tomography (SPECT) on children with autism.METHODS:
Fifty-five children with untreated autism (47 boys and 8 girls, mean age=50.6+/-20.28 months) were selected from among the patients visiting the child and adolescent psychiatric clinic of Seoul National University Hospital. Psychiatrists had diagnosed the participants according to the DSM-IV criteria for autistic disorder and the Childhood Autism Rating Scale (CARS) criteria for a diagnosis of autism. All participants were examined using 99mTC-HMPAO Brain SPECT. Using statistical parametric mapping (SPM) analysis, we compared the participants' SPECT images to standardized SPECT images of normal children, which had been retrospectively selected by the authors, on a voxel by voxel basis. Voxels with a p-value less than .001 were considered to be significantly different.RESULTS:
The autistic group showed significant hypoperfusion in the right medial frontal gyrus, right precentral gyrus, and left precuneus gyrus. In addition, they showed no significant hyperperfusion areas when compared to the control group.CONCLUSION:
The findings of hypoperfusion in the medial-frontal lobe and precuneus are accord with hemodynamic abnormalities that have been already reported. Therefore, these findings are compatible with the recently suggested "theory of mind" hypothesis and the disturbances in attention shifting that have been observed in autistic children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Perfusão
/
Psiquiatria
/
Transtorno Autístico
/
Encéfalo
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Estudos Retrospectivos
/
Tecnécio Tc 99m Exametazima
/
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Hemodinâmica
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Academy of Child and Adolescent Psychiatry
Ano de publicação:
2009
Tipo de documento:
Artigo
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