EFFECT OF CALCIUM ON THE EXPRESSION OF OSTEOCALCIN, PARATHORMONE AND PARATHORMONE RECEPTOR IN RAT EXPOSED TO LEAD / 营养学报
Acta Nutrimenta Sinica
;
(6)1956.
Artigo
em Chinês
| WPRIM
| ID: wpr-561970
ABSTRACT
Objective:
To study the effect of calcium on osteocalcin(OC) and parathyroid hormone (PTH) in rat exposed to lead.Method:
Wistar rats were randomly divided into control group, lead group, low-calcium+lead group and high-calcium+lead group. The content of calcium and lead in bone, OC and PTH of rat with different treatments were detected. At the same time, RT-PCR analysis was used to determine the expression of OC and PTHr1.Results:
Lead decreased the content of calcium in bone and OC. The expression of OC was inhibited, and the level of PTH and the expression of PTHr1 increased, which could be enhanced by low calcium treatment, but high calcium treatment could antagonize these effects of lead.Conclusion:
Supplementation of calcium in diet could extenuate the toxicity of lead on bone in rat.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Nutrimenta Sinica
Ano de publicação:
1956
Tipo de documento:
Artigo
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