Release in-vitro of panax notoginoside micro-porous osmotic pump tablets / 中成药

ABSTRACT

AIM:To study release rate in-vitro of the panax notoginoside micro-porous osmotic pump(MPOP) tablets.METHODS:To investigate the effects of different dissolution methods,paddle stirring rate and dissolved mediums on the release rate in-vitro of the panax notoginoside MPOP tablets.RESULTS:The delivery rate was not influenced by the dissolution methods,paddle stirring rate and when the pH of dissolution medium was between(3.5)-7.6,the delivery rate was not influenced,too.However,when the pH of dissolved medium was at 1.0,the release rate was decreased severely.CONCLUSION:Panax notoginoside MPOP tablets have a stable release curve except for in the condition of the acid dissolved medium.