Clinical analysis of autologous peripheral blood stem cell transplantation for hematologic malignancies in 231 cases / 中国实用内科杂志

ABSTRACT

Objective To evaluate clinical effect of autologous peripheral blood stem cell transplantation(APBSCT)on the treatment of hematologic malignancies.Methods Totally 231 patients(ALL in 45 cases,AML in 34 cases,NHL in 100 cases,HD in 31 cases,MM in 21 cases)with hematologic malignancies received APBSCT from March 2001 to February 2007.Therapeutic effect and complication were oberserved.Results Totally 230 patients obtained hematopoietic reconstitution quickly,one case failed.ALL CR1(first time CR)13 in DFS,4 alive with disease(LWD),11 in death;ALL CR2(second time CR)3 in DFS,4 in LWD,10 in death;AML CR112 in DFS,3 in LWD,6 in death;AML CR26 in DFS,2 in LWD,6 in death;NHL CR43 in DFS,7 in LWD,9 in death;NHL CR218 in DFS,5 in LWD,7 in death;NHL NR2 in DFS,4 in LWD,5 in death;HD CR110 in DFS;HD PR12 in DFS,3 in LWD;HD RE3 in DFS,2 in LWD,1 in death;MM7 in DFS,6 in LWD,8 in death.Conclusion APBSCT is a safe and effective therapy method for treating hematologic malignancies.