Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate / 第三军医大学学报

ABSTRACT

Objective To study the synthesis of methyl bryoanthrathiophene-1-carboxylate with high efficiency. Methods Target compounds were synthesized from 1,8-dihydroxy-9,10-anthraquinone via 5 steps including protecting, nitration, methyl mercaptoacetate substitution, intramolecular Aldol reaction and deprotecting. Results Target molecule was synthesized in the total yield of 45.8%. Conclusion Our synthesis of methyl bryoanthrathiophene-1-carboxylate is characterized by short synthetic route, high selectivity and high efficiency.