Determination of Plasma 5-HT Concentration and its Clinical Significance in Patients with Sudden Deafness / 医学研究杂志

ABSTRACT

Objective To explore the relationship between plasma 5-HT and patients with sudden deafness and the pathogenesis in sudden deafness.Methods 46 inpatients with sudden deafness as patient group,and 34 healthy as control group.They were determined the plasma 5-HT concentration by immunoradiometric assay,then statistics analysis,and investigated negative life events in one week before admission.Results There is significant difference in 5-HT concentration between two groups.In patient group,35 cases(76%) had anxiety,depression emotion and sleep disorder before attack.Conclusions The high level of the plasma 5-HT concentration is probably one of the mechanisms in the patients of sudden deafness.Whether there is relationship between plasma 5-HT concentration and the degree and prognosis of sudden deafness needs to be further studied.