The Effects of Short-term Intensive Therapy with Glargine Versus Glimepiride on ?-cell Function in Newly Diagnosed Type 2 Diabetic Patients / 医学研究杂志

ABSTRACT

Objective To evaluate the effects of two different short-term intensive therapies on ?-cell function in newly diagnosed type 2 diabetic patients.Methods Twenty newly diagnosed type 2 diabetic patients were divided into two groups of 10 patients each and randomly treated with glargine or glimepiride plus metformin for 4 weeks.The improvement of ?-cell function,FPG,PPG,HbA1c were measured before and after intensive therapy in each group.The difference in the improvement of ?-cell function,blood glucose and the frequency of hypoglycemia were compared between groups.Results After the treatment,FPG(12.25 vs.6.05 and 11.83 vs.6.35mmol/L),2hPG(18.67 vs.8.11 and 16.95 vs.8.73mmol/L),HbA1c(8.98% vs.7.38% and 9.17% vs.7.71%) were significantly decreased(all P