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A method for detection of HER2 gene amplification in breast cancer tissues:chromogenic in situ hybridization method and its modification / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12)1982.
Artigo em Chinês | WPRIM | ID: wpr-562878
ABSTRACT

Objective:

To apply chromogenic in situ hybridization(CISH)for detection of HER2 gene amplification in breast cancer tissues and to discuss some modifications of the CISH method.

Methods:

HER2 gene amplification was detected by CISH in 60 breast cancer specimens with an immunohistochemical score over 2+.The correlation between the results of IHC and CISH was analyzed.Our experience in CISH manipulation was summarized and optimization to CISH was discussed.

Results:

CISH identified gene amplification in 91%(40/44)specimens with an IHC score of 3+ and in 50%(8/16)specimens with an IHC score of 2+.The total concordance rate between IHC and CISH was 80%(48/60,P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 1982 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 1982 Tipo de documento: Artigo