The Study on Synthesis on 20(S)-9-nitrocamptothecin / 医学研究杂志
Journal of Medical Research
;
(12)2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-563168
ABSTRACT
20(S)-9-nitrocamptothecin was synthesized from camptothecin by nitration reaction using mixed nitrate salts in sulfuric acid medium.The yield was raised from 31% to 40% after chromatographic purification treatment.The best reaction conditions was as follows0.5 g of camptothecin;30ml of sulfuric acid;0.007mol of nitrate salts(NH4NO3/CaNO3=1/1).The reaction was completed in 24h at 20℃.The advantage of this method is high yield and easily purification.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Medical Research
Ano de publicação:
2006
Tipo de documento:
Artigo
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