Effects of hypertension in different stages on the oxidative susceptibility of low-density lipoprotein in patients with cerebral infarction / 解放军医学杂志

ABSTRACT

Objectives To explore the effects of hypertension on the oxidative susceptibility of plasma low-density lipoprotein (LDL) in patients with cerebral infarction. Methods A total of 79 patients, 39 males and 40 females with mean age of 67?7, with hypertension accompanied by similar size of cerebral infarction in the perfusion domain of middle cerebral artery, were involved in this study. The hypertension was graded as follows grade Ⅰ (n=27), the systolic blood pressure (SBP)/diastolic blood pressure (DBP) was 140-159mmHg/90-99mmHg; grade Ⅱ (n=29) with SBP/DBP of 160-179mmHg/100-109mmHg; grade Ⅲ (n=23) with SBP/DBP exceeding 180mmHg/110mmHg. Serum concentrations of LDL were determined with enzymatic colorimetry employing an automated multianalyzer. The lag time (ox-LDL lag-time) in conjugated diene production at 234nm was determined by copper-stimulated oxidation. Results No statistical difference was found in LDL-total cholesterol, LDL-triglyceride, LDL-free cholesterol among grade Ⅰ, Ⅱ, Ⅲ groups (6.1?0.4, 0.87?0.08, 1.6?0.7mmol/L; 5.7?0.6, 0.86?0.05, 1.8?0.9mmol/L; and 5.6?0.7, 0.87?0.1, 1.7?0.8mmol/L, respectively). Correlation analysis showed the lag time in conjugated diene production in patients with cerebral infarction was negatively related to the grade of hypertension in all the subjects, and the lag time in grade Ⅰ, Ⅱ, Ⅲ groups was 84.26?8.491, 69.84?7.748 and 61.95?8.482 min, respectively (r=0.673 3, P