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Chemical Orchiectomy Using Absolute Alcohol Injection into Rat Testicles / 대한비뇨기과학회지
Korean Journal of Urology ; : 858-862, 1998.
Artigo em Coreano | WPRIM | ID: wpr-56347
ABSTRACT

PURPOSE:

In patients suffering from prostate cancer, endocrine treatment is commonly applied to either locally advanced or metastatic prostate cancer. But, there are many side effects with endocrine treatment in spite of its good response. We studied the effect of castration using absolute alcohol injection into the testis of Sprague-Dawley rats. MATERIALS AND

METHODS:

We checked and compared the serum testosterone level after surgical castration and the injection of a serial amount of alsolute alcohol into the testis of sixty Sprague-Dawley rats. The histologic findings of the testes and prostates in those injected with absolute alcohol were also evaluated.

RESULTS:

The testosterone level of normal control was 2.29 +/-0.47ng/ microliterand that of the bilateral orchiectomy group was 0.03 +/-0.02ng/ml. The testosterone level of the groups that were injected with absolute alcohol more than 25% of testicular weight were the same as the testosterone level of castrated rats. The histologic findings of the testes and prostates in those injected with absolute alcohol more than 25% of testicular weight were diffusely atrophied.

CONCLUSIONS:

We suggest that chemical orchiectomy using absolute alcohol as a new endocrine treatment is another modality in advanced prostatic cancer patients who need an orchiectomy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Neoplasias da Próstata / Testículo / Testosterona / Orquiectomia / Castração / Ratos Sprague-Dawley / Etanol Limite: Animais / Humanos Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Neoplasias da Próstata / Testículo / Testosterona / Orquiectomia / Castração / Ratos Sprague-Dawley / Etanol Limite: Animais / Humanos Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 1998 Tipo de documento: Artigo