INFLUENCE OF FOLIC ACID,VB_6,VB_(12) ON HOMOCYSTEINE IN DIABETES MELLITUS / 营养学报

ABSTRACT

Objective To probe the relationships between homocysteine (Hcy) and folic acid, VB6, VB12. Methods Ninety-eight diabetes mellitus (DM) patients and 31 normal persons were recruited. Fluorescence polarization immunoassay (FPIA) was used to detect Hcy, and double labelled radioimmunoassay to detect folic acid, and VB12. Results The Hcy in DM patients was decreased in folic acid(5 mg/d) group, VB12 (1.5 mg/d), group and folic acid combined with VB12 group. but not in VB6 group. Conclusion Folic acid, VB12, and folic acid combined with VB12 can reduce Hcy in DM patients,but VB6 cannot.