Effects of Saikosaponin a on TNF-? release and its receptor expression in cultured hippocampal astrocytes induced by pentylenetetrazol / 中华中医药杂志
China Journal of Traditional Chinese Medicine and Pharmacy
;
(12)2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-563816
ABSTRACT
Objective:
To study e ects of Saikosaponin a(SSa) on tumour necrosis factor-alpha(TNF-?) release and its receptor expression in cultured hippocampal astrocytes induced by pentylenetetrazol(PTZ).Methods:
The in vitro cultured primary hippocampal astrocytes were randomly divided into control group(group A),PTZ-induced group(group B)PTZ10mmol/L+SSa groups(group C and group D,the SSa concentrations were 1.25mg/L and 0.625mg/L respectively).The extracellular uid TNF-? level and the expression of tumour necrosis factor receptor type 1(TNFR1) in hippocampal astrocytes were respectively detected by ELISA and Western-blot after PTZ-induced 2 hours.Results:
the TNF-? level and TNFR1 expression of group B were signi cantly higher than that of group A,group C and group D(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Journal of Traditional Chinese Medicine and Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo
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