Effects of ClC-3 chloride channel on the Ca~(2+) movement induced by Thapsigargin in PC12 cells / 中国药理学通报

ABSTRACT

0.05).SK & F96365 at the concentration of 5～20 ?mol?L-1 inhibited the Ca2+ influx induced by 1.0 ?mol?L-1 Thapsigargin in a concentration-dependent manner.The inhibitory effect of SK & F96365 on Ca2+ influx was decreased by overexpression of ClC-3 protein.Conclusion ClC-3 chloride channel was involved in the regulation of store-operated Ca2+ entry(SOCE).