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Validation of a Scoring System for Predicting Malignancy in Patients Diagnosed with Atypical Ductal Hyperplasia Using an Ultrasound-Guided Core Needle Biopsy / 한국유방암학회지
Journal of Breast Cancer ; : 407-411, 2012.
Artigo em Inglês | WPRIM | ID: wpr-56438
ABSTRACT

PURPOSE:

The need for surgical excision in patients with ultrasound-guided core needle biopsy (CNB)-diagnosed atypical ductal hyperplasia (ADH) remains an issue of debate. The present study sought to validate a scoring system (the U score, for underestimation) that we have previously developed for predicting malignancy in CNB-diagnosed ADH.

METHODS:

The study prospectively enrolled 85 female patients with CNB-diagnosed ADH who underwent subsequent surgical excision. Underestimation was defined as a surgical specimen having malignant foci.

RESULTS:

The overall underestimation rate was 37% (31/85). Multivariate analysis showed that a clinically palpable mass, microcalcification on imaging, size >15 mm and a patient age of > or =50 years were independently associated with underestimation. When applied to the scoring system, the validation score was significant (p<0.001; area under the curve, 0.852). No patient with a U score <3.5 had an underestimated lesion.

CONCLUSION:

The present study successfully validated the efficacy of our scoring system for predicting malignancy in CNB-diagnosed ADH. A U score of < or =3.5 indicates that surgical excision may not be necessary.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biópsia por Agulha / Neoplasias da Mama / Análise Multivariada / Estudos Prospectivos / Erros de Diagnóstico / Biópsia com Agulha de Grande Calibre / Hiperplasia Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biópsia por Agulha / Neoplasias da Mama / Análise Multivariada / Estudos Prospectivos / Erros de Diagnóstico / Biópsia com Agulha de Grande Calibre / Hiperplasia Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2012 Tipo de documento: Artigo