The Expression and Significance of IGF-1 and survivin in Reactive and Neoplastic Astrocytes / 医学研究杂志
Journal of Medical Research
; (12)2006.
Article
em Zh
| WPRIM
| ID: wpr-564857
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the difference of IGF-1,Bcl-2,survivin and Ki-67 protein expression in reactive and neoplastic astrocytes and the significance of them.Methods Immunohistochemistry and tissue microarray techniques were used to determinate the expression of IGF-1,Bcl-2,survivin and Ki-67 protein in normal brain tissues, astrocytes proliferation,low-grade astrocytomas, and high-grade astrocytomas.Results The expression of IGF-1,Bcl-2,survivin and Ki-67 protein were all negative in control group.The positive expression rates of them in reactive astrocytes were 28.9%, 26.7%, 26.7% and 22.2%,respectvely; and in low-grade astrocytomas were 63.8%, 50.0%, 53.2%,70.2%; in high-grade astrocytomas were 88.9%, 79.2%, 88.1%,95.2%.IGF-1,Bcl-2,survivin and Ki-67 all had significant difference among the three experimental groups(P
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Medical Research
Ano de publicação:
2006
Tipo de documento:
Article