Experimental Study on Qizhu Jianzhong Decoction Influencing Ulcerative Rats’ IL-6 and GAS in Spleen Yang Deficiency / 浙江中医药大学学报

ABSTRACT

[Objective] To explore part of mechanism of Qizhu Jianzhong Decoction treating gastric ulcer and spleen Yang deficiency, impersonally state the scientific connotation of the decoction. [Method] Randomly divide 60 SD rats into normal/ blank control group(Ⅰ), model group(Ⅱ), sucralfate group(Ⅲ), large-dosage group(Ⅳ), middle-dosage group(Ⅴ) and small-dosage group(Ⅵ) of Qizhu Jianzhong Decoction. Except for the group Ⅰ, others are made into rats model of spleen yang deficiency and gastric ulcer with abnormal diet, fatigue, cold and bitter purgation, and cold water stimulant. After being administered medicines, measure their IL-6 and GAS level, and observe the pathological changes of gastric mucosa under microscope. [Result] Compared with group Ⅰ, in the model group, the IL-6 rose, GAS decreased; compared with the model group, other groups of Ⅲ, Ⅳ and Ⅴ all markedly decreased rats serum Ⅱ-6 level and increased GAS level, with obvious difference(P0.05). Under microscope, the gastric mucosa injury degree was less in groups Ⅲ, Ⅳ and Ⅴ than group Ⅱ; and it was similar between group Ⅵ and group Ⅱ. [Conclusion] Groups Ⅳ and Ⅴ have marked cure effect on spleen yang deficiency and gastric ulcer, and group Ⅵ has no obvious cure effect.