Mechanisms of the neuroprotection of astrocyte during cerebral ischemic disease / 中国药理学通报

ABSTRACT

Cerebral vascular diseases throw great threat to human health,among which ischemic stoke accounts for 50%~80%.Rencent results showed that astrocyte can protect the neurons during cerebral ischemia diseases via maintenance extracellular K+ homeostasis,elimination of oxygen free radicals,uptake the excess excitatory amino acid,release of neurotrophic factors and regulation the functions of ion channels.This article reviews the recently published works about the mechanisms of the neuroprotective effects of astrocyte during the cerebral ischemic diseases.