Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics
Korean Journal of Pathology
;
: 93-99, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-56555
ABSTRACT
Acinar cell carcinoma is a rare malignant epithelial neoplasm with predominantly exocrine acinar differentiation and is seen primarily in older men (mean age, 62 years). The presenting symptoms are usually non-specific, and jaundice is often not present. Symptoms relating to the overproduction and release of lipase into the circulation are present in 10-15% of patients. Characteristic cytomorphologic features include a population of cells with minimal pleomorphism, eccentrically placed nuclei with a single prominent nucleoli and moderate hyperchromasia. The cytoplasm is finely granular, and the background may contain granular debris secondary to cytolysis. A significant proportion of the cases also have a minor neuroendocrine component or scattered neuroendocrine cells. Approximately 50% of patients have metastatic disease at presentation, often restricted to the regional lymph nodes and liver. The prognosis is poor, only slightly better than that of pancreatic ductal adenocarcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pâncreas
/
Ductos Pancreáticos
/
Prognóstico
/
Carcinoma
/
Adenocarcinoma
/
Carcinoma de Células Acinares
/
Citoplasma
/
Células Neuroendócrinas
/
Células Acinares
/
Icterícia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2013
Tipo de documento:
Artigo
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