THE CHANGES OF COX-2 AND APOPTOSIS GENE EXPRESSION IN THE INHIBITION EFFECT OF DOCOSAHEXAENOIC ACID ON HUMAN PANCREATIC CANCER CELL IN VITRO / 营养学报

ABSTRACT

Objective To study the changes of COX-2 and apoptosis gene Bcl-2,Bax expression in the inhibition effect of DHA on pancreatic cancer cell lin(ePatu8988)in vitro and investigate the mechanism. Method The inhibition of cell proliferation was evaluated by MTT assay. Cell apoptosis induction and COX-2, Bcl-2, Bax expression were evaluated by flowcytometry. Results DHA could inhabit the proliferation of pancreatic cell and induce cell apoptosis, both of which were time-dependent and dose-dependent(P