Effects of Combined Telmisartan and Ramipril on Heart Function and Renin-angiotensin-aldosterone System and Ventricle Remodeling in Patients with Chronic Congestive Heart Failure / 医学研究杂志

ABSTRACT

Objective To study the effects of combined telmisartan and ramipril on heart function and renin-angiotensin-aldosterone system and ventricle remodeling and brain natriuretic peptide in patients with chronic heart failure(CHF).Methods 100 patients with chronic heart failure were randomly divided into three groups telmisartan group(A group,treated with telmisartan 80mg once daily,n=33),ramipril group(B group treated with ramipril 5mg once daily,n=33) and telmisartan plus ramipril group(treated with telmisartan 40mg plus ramipril 2.5mg once daily,n=34).Left ventricular end-diastolic dimensions(LVEDD) and left ventricular ejection fraction(LVEF) were assessed,and plasma renin activity(Ren),angiotensinII(AngII),aldosterone(Ald) and brain natriuretic peptide(BNP) were measured before and after therphy.Results After 6 months of treatment,LVEDD and LVEF were improved in all groups(P0.01).The concentration of Ald and BNP was decreased in all groups(P