Study on rules of TCM differential treatment of side effects induced by antipsychotic / 中华中医药杂志

ABSTRACT

In clinical, the common side effects of antipsychotic were extrapyramidal symptoms, drug-induced liver injury, sexual dysfunction, amenorrhea, neutropenia, drug-induced dermatitis, digestive disorders, abnormal increase in body weight, etc. According to patients clinical manifestations of side effects of antipsychotics and chinese medical clinic cognitive model of ‘outer appearance from inside essence’, ‘conjecturing the interior by observing the exterior’, ‘analogy by classifi cation’, ‘identifying etiology by symptoms differentiation’, ‘syndrome determination by drugs’, etc., it can be found that in conventional treatment course, different antipsychotic drugs acted on the different human body may induce different side effects and different toxic reaction, generally including stagnation of heat in spleen-stomach, excessive heat in Yangming, excessive heat generating wind, body fluid deficiency generating wind, internal retention of phlegm and dampness, obstruction of collaterals. TCM differential treatment to antipsychotic-induced disease obtained a more signifi cant effect. Clearing away heat, purgative activity, invigorating qi, nourishing yin, activating blood flow, resolving phlegm were the basic treatment methods, of which nourishing yin, activating blood flow were of particular signifi cance.