Effects of Emodin on the Cytoplasmic free Ca~(2+) in Peritoneal Macrophages From Mice / 中草药

ABSTRACT

Effect of Emodin (EMD) on free intracellular Ca2+([Ca2+]i) in peritoneal macrophages of mice was measured with Ca2+ sensitive fluorescent indicator Furi-2/A m quantitatively.Results showed that in the resting, [Ca2+]i level in the peritoneal macrophages was 198.56?44.82nmol/L (n=11) in Ca2+ free Hank's solution. After adding 0.75, 1.75 and 2.75 mmol/L CaCl2 to macrophages suspension sequentially, the free[Ca2+] levels were obviously higher as compared with that of the resting level (P