Correlative study on prevetion and treatment of perimenopausal syndrome and heat shock protein / 中华中医药杂志

ABSTRACT

The period of perimenopausal causes an sudden change of internal environment and disorder of many systems. But the body has a self-adjusting ability, which can help the body to adjust and maintain the body,s state of homeostasis. If this ability too weak or environmental changes in the body is too severe, so that the organism is difficult to reach a new equilibrium, the physiological stress in this time will turn into pathological stress, leading to menopause and menopause syndrome prone to the disease. Heat shock protein in the cell is the stress induced in the broad and non-specific proteins to protect the cells, as a ‘chaperone’ involved in a number of physiological and pathological process of the body. As a result of heat shock protein is induced by stress response in peirmenopausal period and it has an intinate relationship with many links during peirmenopausal period such as neutroendocrine, immunity, antioxidation, estrogen receptor, and insulin receptor, so discussing the function of HSP will benefit the prevention of peirmenopausal syndrome.