Influence of ?-3 PUFA on bacterial pneumonia in mice / 肠外与肠内营养

ABSTRACT

Objective: To evaluate the protective effect and possible mechanism of ?-3 PUFA supplementation in the early stage of experimental acute bacterial pneumonia in mice.Methods: Mice of Pseudomonas aeruginosa(PA)-induced lung injury were randomly divided into three groups: fish oil supplementation treatment group(n = 8),soybean oil treatment group(n = 8) and normal sodium treatment group(n = 8).Evaluation criteria were inflammatory response 24 h after the injury assessed with TNF-?、IL-1?,IL-10 levels in bronchoalveolar lavage and lung injury evaluation by H-E staining.Results: Compared with the other two groups,the levels of IL-1?,IL-10 in fish oil supplementation treatment group were reduced.No difference was found in the TNF-? level and histological scoring among the groups.Conclusion: The ?-3 PUFA can decrease the elevated mediators of inflammation in bacterial pneumonia,but can't affect the pneumonia progress within 24 hours.