The Physicochemical Properties of Lipiodol-Anticancer Drug Emulsion and Suspension / 介入放射学杂志

ABSTRACT

Two types of emulsions and suspensions were prepared using 40% Lipiodol (LIP)and Ultra-Fluid Lipiodol(UFL)with mitomycin C(MMC)by the“pumping techni- que”.The physical stabilities of each preparation were examined microscopically and macro scopically.The drug release test was made by using dissolution tester uhder rotating oar method,the concentrations of MMC released from the preparations were determined spectro- photometrically.The results showed that the emulsion was unstable,underwent phase separation easily and drug release rapidly.The stability of the emulsion was related to the proportion Lipiodol and aqueous solution(oil/water ratio),The ratio of 41 was ruich made stable than that of 21.The stability of the UFL emulsion was better than that of the LIP. The suspension was mare stable than the emulsion.The UFL suspension was much more suitable for clinical use because of not so viscons than the LIP.