Influence of BushenHuoxuefang on the Expression of Platelet Derived Growth Factor BB in Renal Interstitial Fibrosis Rats / 中华中医药杂志

ABSTRACT

Objective: To observe the protective effect of BushenHuoxueFang on renal interstitial fibrosis in rats and try to explore the mechanism. Methods: The renal obstruction model of rats was established by unilateralureteral obstruction ,and then they were divided into four groups randomly, including sham-opration group,model group,Lotensin group, BushenHuoxueFang high-dose and low dose group.The morphological changes of kidney tissue were observed,the level of PDGF-BB was detected by Western-blot on the third,seventh,fourteenth and twenty first,twenty eighth day Results: Compared with the sham-operation group, there were different degrees of kidney lesions in UUO group and the treatment groups. The level of PDGF-BB in UUO group was significantly higher than that in sham-operation group from the third day(P