Analysis on Drug Resistance of Staphylococcus Isolates / 医学研究杂志

ABSTRACT

Objective To explore the drug resistance of Staphylococcus isolates and offer scientific basis for reasonable usage of antibiotics.Methods MIC test was taken by broth microdilution method in 216 strains of Staphylococcus.Methicillin resistant Staphylococcus(MRS)strains were identified by Cefoxitin Kirby-Bauer disk diffusion method.Results The prevalence of methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant coagulase-negative Staphylococci(MRCNS)was 53.7% and 91.9%,respectively.Resistant rates of MRSA and MRCNS were higher than those of methicillin-susceptible Staphylococcus aureus(MSSA) and methicillin-susceptible coagulase-negative Staphylococci(MSCNS) to antimicrobial agents commonly used in clinic.Most of isolates of Staphylococcus were susceptible to synercid.All isolates were susceptible to both vancomycin and linezolid.Conclusion The increase of isolated rates of MRSA and MRCNS and the emerging bacterial resistance warrants further enhancing the detection of MRS and the surveillance of bacterial resistance to inform the rational use of antimicrobial agents and containment of bacterial resistance.