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Clinical usefulness of morphine skin prick test in diagnosis of allergic diseases / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology ; : 476-483, 1999.
Artigo em Coreano | WPRIM | ID: wpr-56745
ABSTRACT

BACKGROUND:

Few studies have demonstrated an enhanced skin responsiveness to opiates in atopic subjects.

OBJECTIVE:

To determine whether the skin response to morphine is increased in atopics and to assess the clinical usefulness of morphine skin prick test in diagnosis of allergic diseases.

METHOD:

Allergy skin prick tests were performed using 55 common allergens, histamine, and morphine in 158 patients with allergic diseases.

RESULTS:

Wheal and flare sizes for morphine (1mg/mL) were significantly related to and smaller than those for histamine (1mg/mL). Although the proportion of subjects with allergic rhinitis and the level of serum total IgE were not different between responders (wheal >- 2mm) and nonresponders to morphine, the positive response rate to allergens was significantly lower in nonresponders. The flare sizes for morphine were significantly higher in positive allergen test group (A/H ratio >- 0.5). Among positive allergen test group, the subjects with atopy score >- 5 showed a larger flare size for morphine than those with atopy score < 5 while the sizes for histamine were not different.

CONCLUSION:

Morphine skin prick test is helpful for detecting false negative responses to allergens, and morphine skin test responses are increased in highly atopic patients probably due to enhanced mast cell releasability.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pele / Imunoglobulina E / Testes Cutâneos / Alérgenos / Histamina / Rinite / Diagnóstico / Hipersensibilidade / Mastócitos / Morfina Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Journal of Asthma, Allergy and Clinical Immunology Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pele / Imunoglobulina E / Testes Cutâneos / Alérgenos / Histamina / Rinite / Diagnóstico / Hipersensibilidade / Mastócitos / Morfina Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Journal of Asthma, Allergy and Clinical Immunology Ano de publicação: 1999 Tipo de documento: Artigo