Airway hyperresponsiveness among workers exposed to isocyanates at Yeocheon petrochemical plant / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
; : 468-475, 1999.
Article
em Ko
| WPRIM
| ID: wpr-56746
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To investigate the prevalence of airway hyperresponsiveness induced by isocyanate at one petrochemical industry complex in Yeochon, Korea. METHOD: Questionnaires, allergic skin prick test, toluene diisocyanate (TDI)-specific IgE, and non-specific airway hyperresponsiveness (AHR) were studied in 73 exposed workers and 27 control subjects. Methacholine challenge tests were done and bronc hial responsiveness (BR index) was defined as log (% fall of FEV1)/ log (last concentration of methacholine +10). RESULTS: Twenty-three workers (31.5% ) had respiratory symptoms, 21 had nasal symptoms, and eight had skin symptoms. Exposed workers with respiratory symptoms (n=22) had significantly higher BR index than those without them (0.82+/-0.06 vs 0.60+/-0.02, p0.05). Specific IgE antibodies were found in 19.7% of exposed workers. FEV, showed a significant negative correlation with BR index (r =-0.25, p<0.05). Poor correlation was noted between BR index and atopy, smoking status, or exposure duration. CONCLUSION: These findings suggest that workers exposed to isocyanates are at higher risk of airway hyperresponsiveness.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plantas
/
Pele
/
Fumaça
/
Imunoglobulina E
/
Fumar
/
Prevalência
/
Inquéritos e Questionários
/
Cloreto de Metacolina
/
Isocianatos
/
Tolueno 2,4-Di-Isocianato
Tipo de estudo:
Prevalence_studies
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
1999
Tipo de documento:
Article