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Pravastatin-induced Stevens-Johnson syndrome
Allergy, Asthma & Respiratory Disease ; : 446-448, 2015.
Artigo em Coreano | WPRIM | ID: wpr-56774
ABSTRACT
Stevens-Johnson syndrome (SJS) manifests with severe cutaneous reactions, most commonly triggered by medications, which are characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis. To our knowledge, pravastatin-induced SJS has not yet been reported. Here, we describe a case of SJS due to pravastatin, which was diagnosed by a patch test. A 70-year-old woman presented with maculopapular skin rashes, which developed 2 weeks after medication of bisoprolol, amlodipine, pravastatin, spironolactone, and indobufene for cardiac problems. Various bullous-erosive mucocutaneous lesions occupied less than 10% of the total body surface area. Painful oropharyngeal mucous membrane lesions were observed. The vermilion border of the lips became denuded and developed serosanguinous crusts. With the drug withdrawal and the use of systemic corticosteroids, her manifestations resolved. Drug patch tests with bisoprolol, amlodipine, pravastatin, spironolactone, and indobufene were performed, resulting in a positive reaction to pravastatin, but not to the other drugs. To the best of our knowledge, this is the first case of pravastatin-induced SJS.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Espironolactona / Superfície Corporal / Testes do Emplastro / Síndrome de Stevens-Johnson / Pravastatina / Corticosteroides / Bisoprolol / Anlodipino / Epiderme / Exantema Limite: Idoso / Feminino / Humanos Idioma: Coreano Revista: Allergy, Asthma & Respiratory Disease Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Espironolactona / Superfície Corporal / Testes do Emplastro / Síndrome de Stevens-Johnson / Pravastatina / Corticosteroides / Bisoprolol / Anlodipino / Epiderme / Exantema Limite: Idoso / Feminino / Humanos Idioma: Coreano Revista: Allergy, Asthma & Respiratory Disease Ano de publicação: 2015 Tipo de documento: Artigo