Primary and secondary focal segmental glomerulosclerosis and comparison of their subtype clinical characteristics / 中国实用内科杂志

ABSTRACT

Objective To compare primary and secondary focal segmental glomerulosclerosis(FSGS)and the clinical characteristics of different subtypes.Methods The clinical and laboratory manifestations of 116 patients with primary and secondary FSGS in China-Japan Friendship Hospital from January of 2001 to December of 2008 were analyzed and compared.Results Of the 116 patients,88 were with primary FSGS(P-FSGS),13 with IgA nephropathy-associated FSGS(IgAN-FSGS),and 15 with obesity-related FSGS(OB-FSGS).Of the 88 patients with P-FSGS,53 were with not otherwise specified(NOS)type(60.2%),18 with cellular type(20.5%),13 with tip type(14.8%),4 with perihilar type(4.5%),and there was no case of collapsing type.Among the total 116 FSGS cases,the frequency of nephrotic syndrome was 41.3%,hypertension 54.3%,hematuria 59.5%,elevated serum creatinine level 44.8% and reduced creatinine clearance 54.3%.More than a half patients presented abnormal proximal or/and distal tubular function.Compared with P-FSGS and IgAN-FSGS,OB-FSGS patients had less proteinuria,higher serum albumin level,lower prevalence of nephrotic syndome,higher CCr and less decreased CCr cases(P