The neuroprotective effect of combining sevoflurane and remote ischemic preconditioning in forebrain ischemia model
Anesthesia and Pain Medicine
;
: 112-116, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-56838
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the combining effects of sevoflurane and remote ischemic preconditioning (RIPC) on cell death of pyramidal neurons in the CA1 hippocampus induced by transient global cerebral ischemia in rats.METHODS:
Twenty rats were assigned to one of two groups; sevoflurane group and combination of sevoflurane and RIPC group. RIPC was performed by occluding the bilateral femoral arteries for 10 min 3 times in an interval of 10 min. Ischemia was induced by a bilateral common carotid artery occlusion plus hemorrhagic hypotension (26-30 mmHg) and was maintained for 8 min. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus.RESULTS:
The combination group contained significantly more viable cells in the hippocampal CA1 area than sevoflurane group (71% vs. 46%, P = 0.03). The mean percentage of apoptotic cells was significantly reduced in the combination group compared to sevoflurane group (11% vs. 41%, P = 0.014).CONCLUSIONS:
A combination of sevoflurane and RIPC can offer additional neuroprotective effects after transient global cerebral ischemia in rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Isquemia Encefálica
/
Prosencéfalo
/
Morte Celular
/
Artéria Carótida Primitiva
/
Células Piramidais
/
Fármacos Neuroprotetores
/
Anestésicos Inalatórios
/
Precondicionamento Isquêmico
/
Artéria Femoral
/
Hipocampo
Limite:
Animais
Idioma:
Coreano
Revista:
Anesthesia and Pain Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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