AUTORADIOGRAPHIC OBSERVATION OF GOSSYPOL EFFECT ON REABSORPTION AND EXCRETION OF ~(42)KCL IN THE RENAL TUBULES / 解剖学报
Acta Anatomica Sinica
;
(6)1989.
Artigo
em Chinês
| WPRIM
| ID: wpr-568843
ABSTRACT
The present study was designed to investigate the effect of gossypol on the reabsorption and excretion of ~(42)K in rats and guinea pigs by using autoradiographic technique, and selected the well known tubulo-toxic agent, gentamicin as a positive control for a comparative study to evaluate whether gossypol exerts nephrotoxic effect. Our results confirmed that gentamicin could induce significant decrease or inhibit ~(42)K reabsorption and cause structural damage of renal tubules. Gossypol could also affect the reabsorption function of proximal tubule, but did not appear to act as a tubulotoxic agent comparable with gentamicin to cause injury of the renal tubules.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Anatomica Sinica
Ano de publicação:
1989
Tipo de documento:
Artigo
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