EFFECT OF RACEMIC (?) GOSSYPOL AND TOTAL GLYCOSIDES FROM TRIPTERYGIUM WILFORDII(GTW) ON HUMAN SPERM ACROSOME REACTION IN VITRO / 解剖学报

ABSTRACT

The effect of racemic(?) gossypol and total glycosides of tripterygium wilfordii (GTW) on human sperm acrosome reaction was observed by indirect immunofluorescence and transmission electron microscopy. The results indicate that recemic (?) gossypol and GTW may significantly inhibit human sperm acrosome reaction induced by ionophore A_(23187) at 5mg/L and 10mg/L respectively. The results of TEM shows that racemic (?) gossypol and GTW may injure the sperm plasma membrane.