Effect of Ginseng and Angelica Sinensis Decoction(GASD) on Learning and Memory of Dementia Rat with Hippocampal Lesions Induced by Quinolinic Acid / 中草药

ABSTRACT

By one trial passive avoidance respense-step-down task and water maze spatial localizat　ion task, the effect of Ginseng and Angelica Sinensis Decotion (GASD)on pathological mod　els of the anmesia rat with hippocampal lesions induced by quiuolinic acid was studied. Re　sults suggest that GASD can improve learning aud memory deficiency in rats with bilateral hippocampal lesions after administration of quinolinic acid. The major mechanism of GASD may be related to the regulation of the glutamatergic fuuction and prevention of the neuro　toxicity of quinolinic acid