GC-MS Assay for Borneol of Compound Danshen Dropping Pill in Serum / 中药新药与临床药理

ABSTRACT

A specific and sensitive GC - MS method for assaying Borneol in the serum of rats medicated orally with compound Danshen dropping pill was developed. Naphthalene was used as the internal standard, the dectection was performed by SIM. The calibration curve was linear in the range from 0.00505 to 40. 1 ?g/mL, the detectable limit of this method was 1 ng/mL. The extraction recovery of Borneol was 72.82% - 86.77%. The RSD of within - day and day - to - day was less than 2.76% and 1.93% respectively. The results showed that this method was simple, sensitive, accurate and good reproducibility , and can be used in further pharmacokinetic study of Borneol in danshen Dropping pill.